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Keep Your Car Cool With The Mercedes Benz Radiator}

Keep Your Car Cool with the Mercedes Benz Radiator

by

[youtube]http://www.youtube.com/watch?v=_Xbh2ivT0gg[/youtube]

Dwyane Thomas

Mercedes Benz was formed through the merging of two companies namely the Daimler-Motoren-Gesellschaft (DMG) and Benz & Cie in June 28, 1926. DMG was founded by Gottlieb Daimler and design partner Wilhelm Maybach in 1890 while Benz & Cie was founded by Karl Benz.

Basing from its history, it is interesting to note that Karl Benz, one of the founders of Mercedes Benz, was the one who first invented the first automobile water radiator.The Mercedes Benz radiator is a part of your car’s cooling system. To keep the engine from overheating is the primary job of the cooling system and it does this by transferring heat to the air since 70% of the energy in the gasoline is converted into heat. Since it keeps your car from overheating, The Mercedes Benz radiator therefore plays a very important role in all internal combustion engines. It is connected to several channels running through the engine and cylinder head, through which a liquid which is usually a mixture of water with ethylene glycol and is called anti-freeze is usually pumped through. This liquid flows through a thermostat and back again to the radiator. Through this process, heat is conducted away from the engine parts, making the vehicle safe from overheating.The Mercedes Benz radiator is a type of heat exchanger. It is designed to transfer heat from the hot coolant that flows through it to the air blown through it by the fan. Nowadays, most of the modern cars use aluminum radiators. These radiators are made by brazing thin aluminum fins to flattened aluminum tubes. The coolant flows from the inlet to the outlet through many tubes mounted in a parallel arrangement. The fins conduct the heat from the tubes and transfer it to the air flowing through the radiator. The Mercedes radiator is commonly mounted behind the car’s grille. This is done to make sure that the fluid stays inside and also because cold air is driven through it in this location. There is also a system of valves installed to simultaneously operate a small radiator called the heater core inside the car. This small radiator serves to warm the vehicle’s interior cabin.The size of the radiator is also taken into consideration in such a way that it can keep the engine at the design temperature under the most extreme conditions a car is likely to encounter. The Mercedes Benz radiator should be checked-up regularly to maintain optimum performance. What could go wrong with it if not maintained properly? First of all, your radiator might overheat. A leaking radiator might be another problem. It is therefore important to check if the radiator is filled with water. When it does overheat and you’re in the middle of the road, don’t panic. First, pull over and stop. Turn of your air conditioning to reduce engine temperature and you can also turn on your car’s heater and set in on the highest temperature setting. Open the hood of your car and let the engine cool off. Check the overflow tank coolant level but be very careful since serious burns can occur because of extreme heat. If it’s empty, then the radiator is probably low on coolant. Check also the pressure of the system by wrapping a cloth around the upper radiator and squeezing it. Aside from this problem of making you pull over every now and then, overheating can not only shorten your engine’s life but can also cause huge damage on your engine. It is therefore important to check the radiator regularly to avoid inconveniences and serious engine problems in the future.

Dwyane Thomas is a part time cook and full-time auto-enthusiast. This 31-year old Civil and Environmental graduate is a consultant at one of the engineering firms in Pennsylvania and an expert in

Mercedes Benz radiator

Article Source:

Keep Your Car Cool with the Mercedes Benz Radiator}

Operation to capture rebel leader surges violence in East Timor

Sunday, March 4, 2007

Several conflicts involving civilians occurred in East Timor at the same time that Australian-led peacekeeping troops stormed a town where a rebel former army officer and his men have been under siege.

The Australian soldiers, supported by helicopters and armored vehicles, stormed the town of Same, 50km south of the capital Dili, at dawn.

Four armed East Timorese men were killed and two others injured during the operation, but their leader, Major Alfredo Reinado, escaped the troops.

The operation was authorised by East Timor’s president, Xanana Gusmão, after Reinado refused to negotiate.

The Major was directly involved in the clashes with the government forces last May, and was later jailed by Portuguese troops for having in his possession dozens of weapons and explosives that he hadn’t handed over to the Australian troops in charge of disarming the rebels. Reinado escaped during a mass breakout from a Dili jail last August.

After the Australian-led operation started, many conflicts occurred simultaneously in different parts of Dili, with roads being barricaded and cut off by burning tires, rocks and trees. Many houses and vehicles were also burned, as violence between rival groups started on the streets.

The Vila Verde neighborhood, right in the center of Dili, was one of the most affected, with facilities of the Education Ministry being engulfed by a fire until the morning.

Benjamin Marty, finance manager for the Norwegian Council for Refugees in East Timor, has his house and office in Vila Verde, in the same street that connects the Portuguese Corporation Neighborhood to the United Nations Integrated Mission in Timor-Leste (UNMIT) headquarters.

“I didn’t get too worried when a saw a group of people starting to hit the gate, but I called my boss, that said me to stay calm.” Bryn Bithell-Marty said.

“Ten minutes later, I see the GNR arrive and starting to fire rubber bullets to the right and to the left” of the street, Marty remembered.

“They called and asked me to open the gate, but initially I didn’t understood what they wanted, because I don’t speak Portuguese. Just in some minutes, I was inside a armored vehicle, and we got out of there at the same speed that they had arrived, deviating from the barricades with a lot of skill”, Marty added.

Benjamin Marty said he was “surprised with the professionalism” with which the Portuguese Republican National Guard (GNR) acted, but he was discontented with members of the United Nations Police (UNPol).

“There’s UNPol near my house, the patrol cars were always stopped and the police agents didn’t do anything», Marty said, adding that the UNPol agents also didn’t react “hours early when some people started to burn tires and hitting metal to call other people to the street”.

The clashes in Taibessi, Pité neighbourhood, and at the entrance of the UNMIT headquarters were the most severe, involving firearms in some locations.

In Banana Road, one of the main roads that crosses the city, a group of teenagers guarded a poster of Alfredo Reinado.

“We are the defenders of Major Alfredo, hero of the justice. We are ready to die to defend him”, said one of them.

In the streets of Taibessi since some days ago that the illumination posts and some trees have posters and banners of Alfredo Reinado.

As a response to the successive attacks by a group on the Pité neighborhood, 15 Portuguese Public Security Police (PSP) officers, organized themselves without orders from the UNPol, and for three hours the 15 officers faced the attacks.

Later back at the GNR headquarters, Benjamin Marty, found himself even more surprised. “Do you know how the Asterix and Obelix stories end?” he said. On the GNR headquarters there wasn’t a party with roasted boars, like in the Gaul village, “but there was a cow in the skewer”, he added.

All of the three GNR operational platoons then left their monthly festivity to the streets of Dili, for a operation that lasted seven hours.

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Bush’s Iraq ‘Strategy’ seen as public relations exercise

Sunday, December 4, 2005

The US commander of the Multinational Security Transition Command in Iraq said that he had no knowledge of the National Strategy for Victory in Iraq document released by the US President. This, along with speculation that the document was chiefly authored by a public opinion analyst recruited by the White House have led to some critics claiming that the drafted ‘strategy’ is targeting US public opinion, not the Iraqi insurgency.

The military, political and economic strategy for Iraq, outlined last week by President Bush in a speech at the Naval Academy in Annapolis, Maryland, was based by a 35-page document titled the National Strategy for Victory in Iraq. A metadata tag on the document posted on the White House website identified its author as a computer user ‘feaver_p’. It is believed to refer to Dr. Peter D. Feaver, a special advisor to the National Security Council staff.

A political scientist at Duke University, Dr. Feaver analyzed public opinion polls about the Iraq war and attitudes towards war casualties. Dr. Feaver found that US public opinion will support military engagement abroad, despite growing casualties, provided that the public believed that the war was being fought for a worthy cause and that victory was achievable.

Dr. Feaver was one of the people who helped “conceive and draft” the document, according to a White House staffer, who said that Meghan L. O’Sullivan, the deputy national security adviser for Iraq and Afghanistan, and her staff played a larger role. White House officials confirmed to the New York Times that the document’s “creation and presentation strongly reflected the public opinion research”.

The document “reflects the broad interagency effort under way in Iraq” according to an NSC spokesman Frederick Jones and had received major contributions from the Departments of Defense, State, Treasury and Homeland Security, as well as the director of National Intelligence.

On Friday, Lt. Gen. Martin Dempsey, whose Multinational Security Transition Command is responsible for building Iraq’s security forces, told reporters that he had seen the strategy document for the first time when it was released to the public. The White House had said that not all senior officers in Iraq had necessarily seen the document and Gen. Peter Pace, the chairman of the Joint Chiefs of Staff, has said that he had read and critiqued the document on several occasions.

Earlier, replying to questions about the President’s strategy, White House press secretary Scott McClellan said that the document was an “inter-agency document” and an “unclassified version” of the administrations “strategy for victory in Iraq” published for the public to view.

Christopher F. Gelpi, of Duke University, who co-authored Dr. Feaver’s work titled Casualty Sensitivity and the War in Iraq, stated, “The Pentagon doesn’t need the president to give a speech and post a document on the White House Web site to know how to fight the insurgents. The document is clearly targeted at American public opinion.” In their work together, Gelpi, Feaver and Reifler found that the most important factor which determines the US public’s tolerance for US military deaths in a war is the public’s beliefs about the likelihood of success, and a secondary, but still important, factor, was found to be the public’s belief in the rightness of a war.

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Officials: Plot to kill Indonesian president foiled

Friday, May 14, 2010

Indonesian authorities said earlier today that they have uncovered a plot by rebels to assassinate several senior government officials, among them president Susilo Bambang Yudhoyono.

National police chief Bambang Hendarso Danuri commented on the matter earlier today, saying that several rebels intended to conduct the attack and declare an Islamic state during the August 17 independence day ceremony. “They were confident that all state officials and dignitaries would be there. Killing all the state officials would have accelerated the transition from a democracy to a state controlled by Islamic Shariah law,” he said.

Danuri added that the attacks also included a plan to attack foreigners and hotels in the capital Jakarta — somewhat similar to the 2008 Mumbai attacks that killed 174 after rebels attacked tourist spots like hotels and a train station.

“Their plan was also to launch attacks in Jakarta against foreigners — especially Americans — and attack and control hotels within certain communities, imitating what happened in Mumbai,” the police chief said. “If we had not detected them and their military training had been successful, then they would have assassinated foreigners.”

The plot was revealed in part due to several anti-terror raids near the capital, which saw twenty people arrested. Many of those now in custody were reportedly trained at a camp in Aceh, and operated by a branch of the Jemaah Islamiyah group called al-Qaeda in Aceh.

This is reportedly the second alleged plot to assassinate the Indonesian president in a year; last August, security forces said they had evidence suggesting rebels would blow up a car by Yudhonoyo’s motorcade. The last large rebel attack was in last July, when suicide bombers targeted hotels in the capital.

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Forex Trading In Pakistan

Submitted by: Christopher Granger

Forex trading in Pakistan has been developing at a fast rate, and regular people are now producing more profit through currency pair trading. Even though a lot of people in the trade industry are around Lahore and Karachi, there are still several more people joining from the other areas. The foreign exchange trade, or more commonly known as Forex, is a large market and only financial firms and big banks was to be involved until recently. Today, almost any individual with an Internet connection can be involved in Forex trading because of its fast development and the introduction of broker spot trade.

When it comes to Forex trading in Pakistan, among the biggest obstacles for trading was language. English may not be the main language of Pakistan, but there is an increasing use of the language around the country. Thus, more and more Pakistanis are starting to get comfortable with the Forex trading world. Only a basic comprehension of English is sufficient to be a Forex trader. What you have to understand most importantly are the charts and figures. If you have no trouble with this part of the deal, then you may go on to the next step, which is finding the best online Foreign exchange broker in Pakistan.

[youtube]http://www.youtube.com/watch?v=jM3_5qp-dXk[/youtube]

There are a lot of factors to mull over when selecting the best Forex broker for you. Some of these include: the withdrawing and depositing alternatives they support; the minimum quantity you require depositing in order to begin trading; whether they provide a demonstration profile with play cash to practice your techniques or not; the performance of the support staff; how much they are obtaining as spread; whether their interface is user and beginner friendly, and up to standards; as well as plenty of other factors. Considering all these factors, you may come up with the conclusion that the best Forex trading in Pakistan is E-Toro. E-Toro is generally deemed on of the finest beginner-friendly Forex interfaces offered all over the world, and was deemed the most ground-breaking trading interface in 2010. With its existing features such as the Forex marathon, live chat with other Forex traders, and Forex chart, E-Toro is a terrific place for a novice to learn the strategies of the trading system.

If you have finally chosen the ideal Forex broker in Pakistan for you, you may then start learning the fundamentals of Forex trading. You must try new techniques in your demonstration profile and enhance your skills. It is recommended to make use of your demo profile for at least one month prior to involving yourself with the real trade.

An important thing to take not of is that even though you may begin investing your profile with as small as $25, you may want to invest larger amount as you may benefit from excellent offers such as first-time deposit bonuses. For instance, E-Toro offers a first-time deposit bonus of 50 percent for deposits of $1,000 at most. This means that if you invest $200, you will get an additional $100.

About the Author: Are you looking for more information regarding

Forex trading in Pakistan

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Antje Duvekot on life as a folk singer, her family and her music

Sunday, November 11, 2007

Boston-based singer-songwriter Antje Duvekot has made a name for herself in the folk music world with powerful ballads of heartbreak and longing for a deeper spirituality, but coming up empty-handed. Below is David Shankbone’s interview with the folk chanteuse.


David Shankbone: Tell me about your new album.

Antje Duvekot: It’s called Big Dream Boulevard and it’s the first studio album I made. It’s not so new; I made it in May of 2006. It’s produced by Séamus Egan, who is the leader of a fairly renowned band named Solas.

DS: You mentioned you used to explore more dark themes in your work, but that lately you are exploring lighter fare. What themes are you exploring on this album?

AD: In the future I am hoping for more light themes. I feel like I have worked through a lot of the darkness, and personally I feel like I’m ready to write a batch of lighter songs, but that’s just how I’m feeling right now. My last record, Big Dream Boulevard, was a pretty heavy record and that was not intentional. I write what is on my mind.

DS: What were you going through that made it so dark?

AD: The record is drawn from my whole writing career, so it’s old and new songs as well. I wasn’t going through anything in particular because it was spanning a wide time period. I think it’s fair to say that over all I turn to music in times of trouble and need as a therapeutic tool to get me through sadness. That’s why I tend to turn to music. So my songs tend to be a little darker, because that’s where I tend to go for solace. So themes like personal struggle with relationships and existential issues.

DS: What personal relationships do you struggle with?

AD: A lot of my songs are about dating and relationship troubles. That’s one category. But a lot of my songs are about existential questions because I struggle with what to believe in.

DS: Do you believe in a higher power?

AD: I’m sort of an atheist who wishes I could believe something.

DS: What do you believe?

AD: It’s undefined. I think I’m spiritual in music, which is my outlet, but I just can’t get on board with an organized religion. Not even Unitarianism. I do miss something like that in my life, though.

DS: Why do you miss having religion in your life?

AD: I think every human being craves a feeling that there is a higher purpose. It’s a need for me. A lot of my songs express that struggle.

DS: Does the idea that our lives on Earth may be all that there is unsettle you?

AD: Yes, sure. I think there’s more. I’m always seeking things of beauty, and my art reflects the search for that.

DS: You had said in an interview that your family wasn’t particularly supportive of your career path, but you are also saying they were atheists who weren’t curious about the things you are curious about. It sounds like you were a hothouse flower.

AD: Yes. I think what went with my parents’ atheism was a distrust of the arts as frivolous and extraneous. They were very pragmatic.

DS: They almost sound Soviet Communist.

AD: Yeah, a little bit [Laughs]. They had an austere way of living, and my wanting to pursue music as a career was the last straw.

DS: What’s your relationship with them now?

AD: I don’t actually speak to my mother and stepfather.

DS: Why?

AD: A lot of reasons, but when I was about 21 I was fairly certain I wanted to go the music path and they said, “Fine, then go!”

DS: That’s the reason you don’t speak with them?

AD: That’s the main. “Go ahead, do what you want, and have a nice life.” So the music thing cost the relationship with my parents, although I think there may have been some other things that have done it.

DS: That must be a difficult thing to contend with, that a career would be the basis for a relationship.

AD:Yes, it’s strange, but my love of music is perhaps stronger for it because of the sacrifices I have made for it early on. I had to fight.

DS: Would you say in your previous work some of your conflict of dating would have been birthed from how your relationship with your family? How do you see the arc of your work?

AD: My songs are sort of therapy for me, so you can trace my personal progress through them [Laughs]. I think there is some improvement. I wrote my first love song the other day, so I think I’m getting the hang of what relationships are all about. I’m ever grateful for music for being there for me when things weren’t going so well.

DS: Has the Iraq War affected you as an artist?

AD: Not directly, but I do have a few songs that are political. One about George Bush and the hypocrisy, but it’s very indirect; you wouldn’t know it was about George Bush.

DS: How has it affected you personally?

AD: I feel sad about it. People say my music is sad, but it’s a therapeutic thing so the war affects me.

DS: The struggle to be original in art is innate. When you are coming up with an idea for a song and then you all of a sudden stumble across it having been done somewhere else, how do you not allow that to squelch your creative impulse and drive to continue on.

AD: That’s a good question. I started writing in a vacuum just for myself and I didn’t have a lot of feedback, and I thought that what I’m saying has been said so many times before. Then my songs got out there and people told me, ‘You say it so originally’ and I thought ‘Really?!’ The way I say it, to me, sounds completely trite because it’s the way I would say it and it doesn’t sound special at all. Once my record came out I got some amount of positive reviews that made me think I have something original, which in turn made me have writer’s block to keep that thing that I didn’t even know I had. So now I’m struggling with that, trying to maintain my voice. Right now I feel a little dried-out creatively.

DS: When I interviewed Augusten Burroughs he told me that when he was in advertising he completely shut himself off from the yearly ad books that would come out of the best ads that year, because he wanted to be fresh and not poisoned by other ideas; whereas a band called The Raveonettes said they don’t try to be original they just do what they like and are upfront about their influences. Where do you fall in that spectrum?

AD: Probably more towards Augusten Burroughs because when I first started writing it was more in a vacuum, but I think everyone has their own way. You can’t not be influenced by your experience in life.

DS: Who would you say are some of your biggest influences in the last year. Who have you discovered that has influenced you the most?

AD: Influence is kind of a strong word because I don’t think I’m taking after these people. I’ve been moved by this girl named Anais Mitchell. She’s a singer-songwriter from Vermont who is really unique. She’s just got signed to Righteous Babe Records. Patty Griffin just moves me deeply.

DS: You moved out of New York because you had some difficulty with the music scene here?

AD: I feel it is a little tougher to make it here than in Boston if you are truly acoustic folk lyric driven. I find that audiences in New York like a certain amount of bling and glamor to their performances. A little more edge, a little cooler. I felt for me Boston was the most conducive environment.

DS: Do you feel home up in Boston?

AD:I do, and part of that is the great folk community.

DS: Why do you think Boston has such a well-developed folk scene?

AD: It’s always historically been a folk hub. There’s a lot of awesome folk stations like WUMB and WERS. Legendary folk clubs, like Club Passim. Those have stayed in tact since the sixties.

DS: Is there anything culturally about Boston that makes it more conducive to folk?

AD: Once you have a buzz, the buzz creates more buzz. Some people hear there’s a folk scene in Boston, and then other people move there, so the scene feeds itself and becomes a successful scene. It’s on-going.

DS: Do you have a favorite curse word?

AD: [Giggles] Cunt. [Giggles]

DS: Really?! You are the first woman I have met who likes that word!

AD: Oh, really? I’ll use it in a traffic situation. Road rage. [Laughs]

DS: Do you find yourself more inspired by man-made creations, including people and ideas, or nature-made creations?

AD: I love nature, but it is limited. It is what it is, and doesn’t include the human imagination that can go so much further than nature.

DS: What are some man made things that inspire you?

AD: New York City as a whole is just an amazing city. People are so creative and it is the hub of personal creativity, just in the way people express themselves on a daily basis.

DS: Do you think you will return?

In theory I will return one day if I have money, but in theory you need money to enjoy yourself.

DS: What trait do you deplore in yourself?

AD: Like anyone, I think laziness. I’m a bit a hard on myself, but there’s always more I can do. As a touring singer-songwriter I work hard, but sometimes I forget because I get to sleep in and my job is not conventional, and sometimes I think ‘Oh, I don’t even have a job, how lazy I am!’ [Laughs] Then, of course, there are times I’m touring my ass off and I work hard as well. It comes in shifts. There are times there is so much free time I have to structure my own days, and that’s a challenge.

DS: When is the last time you achieved a goal and were disappointed by it and thought, “Is that all there is?” Something you wanted to obtain, you obtained it, and it wasn’t nearly as fulfilling as you thought it would be.

AD: I was just thinking about the whole dream of becoming a musician. I want to maybe do a research project about people’s dreams and how they feel about them after they come true. It’s really interesting. They change a lot. When I was 17 I saw Ani Difranco on stage and I wanted to do that, and now I’m doing it. Now I think about Ani very differently. I wonder how long it took her to drive here, she must be tired; I’m thinking of all the pragmatic things that go on behind the scenes. The backside of a dream you never consider when you’re dreaming it. To some extent, having my dream fulfilled hasn’t been a let-down, but it’s changed. It’s more realistic.

DS: What is a new goal?

AD: Balance. Trying to grow my career enough to make sure it doesn’t consume me. It’s hard to balance a touring career because there is no structure to your life. I’m trying to take this dream and make it work as a job.

DS: How challenging is it to obtain that in the folk world?

AD: There’s not a lot of money in the folk world. In generally right now I think people’s numbers are down and only a few people can make a living at it. It’s pretty competitive. I’m doing okay, but there’s no huge riches in it so I’m trying to think of my future and maintain a balance in it.

DS: Do you think of doing something less folk-oriented to give your career a push?

Not really, I’ve done that a little bit by trying to approach the major labels, but that was when the major labels were dying so I came in at a bad time for that. I found that when it comes to do it yourself, the folk world is the best place to make money because as soon as you go major you are paying a band.

DS: More money more problems.

AD: More money, more investing. It’s a hard question.

DS: What things did you encounter doing a studio album that you had not foreseen?

AD: Giving up control is hard when you have a producer. His vision, sometimes, is something you can’t understand and have to trust sometimes. See how it comes out. That was hard for me, because up until now I have been such a do it yourself, writing my own songs, recording them myself.

DS: What is your most treasured possession?

AD: I’d like to say my guitar, but I’m still looking for a good one. I have this little latex glove. [Laughs] It’s a long story—

DS: Please! Do tell!

AD: When I was in college I had a romantic friend named David, he was kind of my first love. We were young and found this latex glove in a parking lot. We though, “Oh, this is a nice glove, we’ll name him Duncan.”

DS: You found a latex glove in a parking lot and you decided to take it?

AD: Yeah [Laughs]. He became the symbol of our friendship. He’s disgusting at this point, he’s falling apart. But David and I are still friends and we’ll pass him back and forth to each other every three years or so when we’ve forgotten his existence. David surprised me at a show in Philly. He gave Duncan to the sound man who brought it back stage, and now I have Duncan. So he’s kind of special to me.

DS: If you could choose how you die, how would you choose?

AD: Not freezing to death, and not in an airplane, because I’m afraid of flying. Painlessly, like most people. In my sleep when I’m so old and senile I don’t know what hit me. I’d like to get real old.

DS: Would you be an older woman with long hair or short hair?

AD: I guess short hair, because long hair looks a little witchy on old people.

DS: Who are you supporting for President?

AD: I’m torn between Obama and Hillary. Someone who is going to win, so I guess Hillary.

DS: You don’t think Obama would have a chance of winning?

AD: I don’t know. If he did, I would support Barack. I don’t really care; either of those would make me happy.

DS: What trait do you value most in your friends?

AD: Kindness.

DS: What trait do you deplore in other people?

AD: Arrogance. Showiness.

DS: Where else are you going on tour?

AD: Alaska in a few days. Fairbanks, Anchorage and all over the place. I’m a little nervous because I will be driving by myself and I have this vision that if I get hit by a moose then I could freeze to death.

DS: And you have to fly up there!

AD: Yeah, and I hate flying as well—so I’m really scared! [Laughs]

DS: Is there a big folk scene in Alaska?

AD: No, but I hear people are grateful if anyone makes it up there, especially in the winter. I think they are hungry for any kind of entertainment, no matter the quality. [Laughs] Someone came to us! I actually played there in June in this town called Seldovia, that has 300 people, and all 300 people came to my gig, so the next day I was so famous! Everyone knew me, the gas station attendant, everyone. It was surreal.

DS: So you had that sense of what Ani DiFranco must feel.

AD: Yeah! I was Paul McCartney. I thought this was what it must be like to be Bruce Springsteen, like I can’t even buy a stick of gum without being recognized.

DS: Did you like that?

AD: I think it would be awful to be that famous because you have moments when you just don’t feel like engaging.
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Eric Bogosian on writing and the creative urge

Thursday, April 17, 2008

Eric Bogosian is one of America’s great multi-dimensional talents. “There’s sort of three different careers, and any one of them could exist by itself, on its own two feet. There was that solo stuff, and then I started writing plays in the late seventies.” Although his work has spanned genres, most readers will recognize Bogosian for his acting, which has included a memorable performance in Woody Allen‘s Deconstructing Harry to co-writing and starring in the Oliver Stone movie Talk Radio (based upon his Pulitzer Prize-nominated play) to playing the bad guy in Under Siege 2 to his current role in Law & Order: Criminal Intent as Captain Danny Ross. They may not know, however, that he had collaborated with Frank Zappa on a album, worked with Sonic Youth, and was a voice on Mike Judge‘s Beavis & Butthead Do America. He started one of New York City’s largest dance companies, The Kitchen, which is still in existence. He starred alongside Val Kilmer in Wonderland and his play Talk Radio was recently revived on Broadway with Liev Schreiber in the role Bogosian wrote and made famous.

Currently at work on his third novel, tentatively titled The Artist, Bogosian spoke with David Shankbone about the craft of writing and his life as a creative.

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Sunflower oil saves at-risk newborns from infection

Saturday, March 5, 2005Simply massaging low birth weight babies with sunflower seed oil can protect them from potentially fatal infections.

Infections and complications from preterm birth cause more than half of all neonatal deaths, and very low birth weight babies are particularly vulnerable.

Preterm babies have immature skin that lacks a protective film called vernix that has antimicrobial properties.

In some countries, such as India, newborns are routinely massaged with mustard oil.

But mustard oil, says Gary Darmstadt of John Hopkins University in Baltimore, Maryland, can delay recovery of the skin barrier and have a toxic effect on skin.

Seeking an alternative low-cost product, Darmstadt and colleagues experimented with sunflower oil and an ointment called Aquaphor that comprises petrolatum, mineral oil, mineral wax and lanolin.

The researchers tested the treatments on 497 newborns (72 hours old or less) and preterm babies (less than 33 weeks gestation) between 1998 and 2003 in Bangladesh.

They applied the treatments to the entire body besides the scalp and face three times daily for the first 14 days and then twice daily until discharge.

Babies treated with sunflower oil were found 41% less likely to develop infections than controls.

“Evidence is emerging that the skin is much more important as a barrier to infection than previously recognized, particularly in preterm infants whose skin is underdeveloped,” says Darmstadt. “The good news is that treatment is available to strengthen the function of the skin as a barrier in these vulnerable newborns.”

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Formulation Development: Amorphous Dispersions In Pharmaceutical Development

Submitted by: Bruce Rehlaender, Ph.D.

Background

Many new drug molecules have solubility problems with some having almost no aqueous solubility. This creates formulation development issues since many standard formulation techniques may not be successful in delivering a drug orally. A common approach to improving oral delivery is to use the amorphous form of an active pharmaceutical ingredient. The amorphous form will have higher apparent solubility compared to its crystalline counterpart. This improvement in apparent solubility can be a strategy to increase oral absorption and bioavailability when in-vivo dissolution is the rate-limiting step. In general, the increased surface area exposure of the amorphous form can decrease time for drug to solvate and be absorbed.

Benefits

The key benefit of the higher apparent solubility is a faster dissolution rate which may lead to higher bioavailability when poorly water soluble drugs can be enhanced with this technique. The higher dissolution can also improve exposure with a more rapid onset and some cases allow a lower dose than needed for a crystalline form of the drug.

Downsides

[youtube]http://www.youtube.com/watch?v=v8S3b9puiKk[/youtube]

The major disadvantage of using an amorphous form is their enhanced properties are offset by the decreased physical and chemical stability relative to the crystalline form. Amorphous solids are metastable and may recrystallize during storage,. Another limitation occurs during dissolution where trace amounts of crystalline drug may act as nucleating agents when the drug is introduced to aqueous media. Another issue is when an amorphous solid is undergoing dissolution. The supersaturated solution generated in the dissolution media around this solid is thermodynamically metastable or unstable and may undergo a phase transformation to a lower free energy state. At supersaturation there will be a thermodynamic driving force for crystallization from solution to a more stable crystalline form. If this phase transition takes place rapidly, the actual supersaturation will be much lower than expected and the benefits of the amorphous form will be lost.

Techniques

A common technique to stabilize an amorphous form in solid state and to protect from phase transition during dissolution is to formulate the drug as a solid dispersion. This formulation is a mixture of the API in the amorphous form with a solid dispersion with a second component, such as a polymer. The stabilizing of amorphous APIs has been attributed to an antiplasticization effect since solid dispersions typically possess higher glass transition temperatures than the pure amorphous drug thus resulting in a lower molecular mobility that prevents phase transition. The stability may also be due to formation of specific drug-polymer interactions such as hydrogen bonds.

There are many cases where the addition of a polymer significantly delayed the onset of crystallization in the solid state. This physical stabilization has been attributed to several factors, such as reduction in molecular mobility, reduction in the thermodynamic driving force for crystallization, increase in the energy barrier for crystallization, disruption of molecular recognition necessary for drug crystallization, or a combination of these factors. Regardless of the specific mechanism, drug polymer blends are more resistant to drug crystallization than the amorphous drug alone. Polymers that are commonly used to stabilize the amorphous state during storage include HPMC, HPMCAS, HPMCP, CAP, Eudragit and Povidone.

An approach is to use an amorphous dispersion where there is an intimate mixture of a drug and a polymer in which the polymer disperses the drug and helps to maintain it in an amorphous form. In this system the drug is dispersed on a molecular level and its release is controlled by erosion of the polymer framework rather than by the dissolution of the drug. This can provide a dissolution pattern that is an independent mechanism of controlled release.

The formulation development team has a number of techniques available to stabilize amorphous drugs with polymers. In a dispersion processes, the API and polymer are heated until they melt or a molten drug or dissolved in a molten polymer. The melt is then extruded, cooled and milled. In a spray drying process, a solution of the drug and polymer in a common solvent is sprayed and dried thus forming a highly concentrated drug/polymer gel also known as a solid solution. The hot melt extrusion has gained popularity for preparing solid dispersion due to many advantages, such as free of solvents, simple procedures and uniform product quality. Co-crystallization is another solid state approach which improves the apparent solubility of the without compromising its structural integrity and bioactivity.

Conclusion

In the formulation development of poorly soluble compounds, forming and stabilizing the amorphous drug has become an important approach when attempting to produce a drug product that will perform consistently over time. These formulations can maintain the performance benefit of an amorphous form while preventing phase transitions during storage thus allowing for the development of viable pharmaceutical products containing a poorly soluble drug.

Look for more articles like this one by searching for “PharmaDirections Formulation Development Blog”.

About the Author: Bruce Rehlaender, Ph.D., Principal, Formulation Development at

PharmaDirections

, a pharmaceutical consulting and project management company specializing in

preclinical development

,

CMC

and

regulatory affairs

. We design and direct preclinical programs for biotech firms.

Source:

isnare.com

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