canyadigit.net

Wednesday, March 23, 2011

By causing the mutation of one specific gene, researchers have produced mice with two frequently encountered behavioral traits of persons diagnosed with autism. Autism commonly affects the ability to interact socially and is associated with repetitive behavior. The finding was reported in the March 20 online edition of Nature.

Using mice, researchers at the Massachusetts Institute of Technology (MIT) and Duke University mutated one of the genes associated with autism, known as shank3, a gene that controls the production of the shank3 protein present in the brain. Mice that were given this mutation exhibited repetitive behavior and avoided social interactions with the mice around them.

According to MIT Professor Guoping Feng: “Our study demonstrated that Shank3 mutation in mice lead to defects in neuron-neuron communications.”

Shank3 protein are found in synapses within the brain. Synapses allow brain cells (called neurons) to communicate with each other. The mutation in the mouse gene interfered with this communication, apparently producing the subsequent autism-like traits. Researchers believe their work demonstrates the important role of shank3 in the functioning of brain circuits that determine behavior.

While hundreds of genes have been linked to autism in human patients, only a small percentage have been linked to shank3. Professor Feng hypothesizes that disruptions of other genes that act on the production of brain proteins affecting synaptic communication may also be related to autistic behavior. If this disruption is real, Feng claims that treatments could be developed to correct synaptic function for any defective synaptic protein in an autistic patient.

Feng continued; “These findings and the mouse model now allow us to figure out the precise neural circuit defects responsible for these abnormal behaviours, which could lead to novel strategies and targets for developing treatment.”

About one in 110 children in the U.S., and at least one in 100 in UK, have been diagnosed with an autism spectrum disorder, for which there is currently no effective cure.

Sunday, June 27, 2010

Toyota announced on Friday that it will recall around 17,000 Lexus vehicles in response to risks of the fuel tank in the cars leaking after a collision.

The Lexus HS 250h model was subjected to the recall following a US National Highway Traffic Safety Administration (NHTSA) investigation. Despite previously passing Toyota safety inspections, the conclusions of an NHTSA sub-contracted investigator were that; when the vehicles in question collided with an object at more than fifty-miles-per hour, more than 142 grams of fuel, the maximum allowed by US law, leaked from the crashed car.

According to Toyota, further tests did not show any additional failure of the fuel tank.

In response to the findings, Toyota issued a recall of all affected vehicles, since the company had no solution immediately available. The recall includes 13,000 cars already sold, as well as another 4,000 still at dealerships.

Toyota says it plans to conduct further tests to determine the cause of the leak. A Toyota spokesman, Brian Lyons, said that the company was “still working to determine what the root cause of the condition is.” It’s still unclear when exactly the recall will take place, or when dealerships will be allowed to sell this model again. Lyons said that Toyota is “working feverishly to get this resolved as soon as possible.”

Toyota isn’t aware of any accidents stemming from the leaking fuel tank in the affected vehicles, first introduced in the summer of 2009.

Saturday, January 23, 2021

On Wednesday, at least four people killed by an explosion at a residential building located in Central Madrid, Spain.

Eyewitnesses reported a strong smell of gas shortly before the blast. The building was owned by a Roman Catholic Church and was destroyed by the blast. Among the dead was an electrician who was present to inspect the building’s boilers.

At least ten others were injured as a result of the incident. According to the reports, strong gas smell had first been detected at around 2pm local time, so an electrician David Santos Muñoz had been called out to inspect the boilers. Minutes after this, at 2:56 pm, the building exploded, killing him and at least three others. An owner of a nearby bar told El País “It was as if a bomb had dropped, the noise was tremendous”. An eyewitness also told the newspaper “it was like an earthquake; I thought a bomb had gone off.”

A school and nursing home were nearby to the blast, the latter of which had suffered minor damage according to the city’s mayor José Luis Martínez-Almeida. Nobody was injured in either of these and TVE said that the school has been said to have been empty at the time due to closures after significant snowfall in the capital. Police said the nursing home was safely evacuated following the blast.

Sunday, February 13, 2005

New York —”Buy cheap Viagra through us – no prescription required!” Anyone with an active email account will recognize lines like this one. According to some reports, unsolicited advertisements (spam) for Viagra and similar drugs account for one in four spam messages.

Ever since pharmaceutical giant Pfizer promised to cure erectile dysfunction once and for all with its blue pills containing the drug sildenafil citrate, spammers have tried to tap into male anxiety by offering prescription-free sales of unapproved “generic” Viagra and clones such as Cialis soft tabs. Legislation like the U.S. CAN-SPAM act has done little to stem the tide of email advertising the products.

Now Pfizer has entered a pledge with Microsoft Corporation, the world’s largest software company, to address the problem. The joint effort will focus on lawsuits against spammers as well as the companies they advertise. “Pfizer is joining with Microsoft on these actions as part of our shared pledge to reduce the sale of these products and to fight the senders of unsolicited e-mail that overwhelms people’s inboxes,” said Jeff Kindler, executive vice president at Pfizer.

Microsoft has filed civil actions against spammers advertising the websites CanadianPharmacy and E-Pharmacy Direct. Pfizer has filed lawsuits against the two companies, and has taken actions against websites which use the word “Viagra” in their domain names. Sales of controlled drugs from Canadian pharmacies to the United States are illegal, but most drugs sold in Canada have nevertheless undergone testing by the U.S. Food and Drug Administration. This is not the case for many of the Viagra clones sold by Internet companies and manufactured in countries like China and India. While it was not clear that CanadianPharmacy was actually shipping drugs from Canada, Pfizer’s general counsel, Beth Levine, claimed that the company filled orders using a call center in Montreal, reported the Toronto Star.

For Microsoft’s part, they allege that the joint effort with Pfizer is part of their “multi-pronged attack on the barrage of spam.” As the creator of the popular email program Outlook, Microsoft has been criticized in the past for the product’s spam filtering process. Recently, Microsoft added anti-spam measures to its popular Exchange server. Exchange 2003 now includes support for accessing so-called real-time block lists, or RTBLs. An RTBL is a list of the IP addresses maintained by a third party; the addresses on the list are those of mailservers thought to have sent spam recently. Exchange 2003 can query the list for each message it receives.

Wednesday, October 21, 2009

A Scottish lawyer today denied reports that Lockerbie bomber Abdelbaset Ali Mohmed Al Megrahi had died, after it was reported on Sky News earlier today that “unidentified sources” had said that he was dead.

The reports came onto Sky News at around 16.00 BST today. The information could not be confirmed, and it was not immediately clear where Sky News had obtained their information. Megrahi is suffering from terminal prostate cancer. Scottish Cabinet Secretary for Justice Kenny MacAskill MSP decided on 20 August 2009 to grant Megrahi compassionate release from Greenock Prison in Glasgow, Scotland and to allow him to return to Libya, after medical advisers reported that he was likely to die in just three months.

On Wednesday, Megrahi’s lawyer, Tony Kelly, responded to the claims made, saying that “it’s absolutely untrue. He’s definitely not dead. I’m not saying anything about his health condition other than the fact he is alive and breathing.” He declined to release any information about Abdelbaset’s current health condition. Following these comments, Sky News removed the information from their website.

Wednesday, January 26, 2022

On Tuesday, the day preceding Australia Day, the Australian government announced it had purchased the copyright to the Australian Aboriginal Flag for A$20.05 million.

The flag, created by Luritja man Harold Thomas in 1970, represents the connection Aboriginal people have to the land. It was adopted as a national flag in 1995, however copyright remained with Thomas. The flag could not be used without his approval or compensation.

Australian Prime Minister Scott Morrison promised the flag would be treated in a comparable way to the national flag, which can be used by anyone so long as it is displayed in a “respectful and dignified way.”

Morrison promised: “All Australians can now put the Aboriginal Flag on apparel such as sports jerseys and shirts, it can be painted on sports grounds, included on websites, in paintings and other artworks, used digitally and in any other medium without having to ask for permission or pay a fee,”

“We’ve freed the Aboriginal Flag for Australians.”

Indigenous Affairs Minister Ken Wyatt said: “Over the last 50 years we made Harold Thomas’ artwork our own — we marched under the Aboriginal Flag, stood behind it, and flew it high as a point of pride,”

“Now that the Commonwealth holds the copyright, it belongs to everyone, and no-one can take it away.”

The commercial arrangements surrounding the flag were highlighted in 2019 after one of the clothing companies holding a licence for the flag, WAM Clothing, gave notices to the National Rugby League and Australian Football League, alleging jerseys worn at their Indigenous round infringed upon their copyright. At the time, Wyatt urged football fans to show their objections to the claim by clothing themselves in the flag. It is understood several other organisations were given similar notices.

Under the agreed deal, the government paid A$20.05 million to Thomas and licence holders to secure copyright and buy back the rights of licence holders. They have pledged to:

• transfer future royalties from commercial flag sales into a fund to support NAIDOC Week;
• establish a A$100 thousand scholarship in Thomas’ honour for Indigenous students to develop leadership skills;
• accept and display a painting by Thomas celebrating the flag’s 50th anniversary and the transfer of copyright;
• create a web portal for flag history and education.

Bangarang woman Geraldine Atkinson told Nine News she was “absolutely pleased” about the flag passing to the government, saying the news gave Indigenous Australians something to celebrate on Australia Day. Atkinson said: “When I read it, it was the first I’d heard about it, and I punched the air, I was so excited […] We’re not going to be celebrating the day, but we’re going to be celebrating our flag. We’re going to be celebrating that we can fly our flag, and wear it on our shirts.”

While Greens Senator Lidia Thorpe welcomed the news, she was wary about the deal, saying: “I’m concerned that the Commonwealth owns the copyright over our flag and what that means for the unceded sovereignty and the self-determination of our people […] We need to have genuine conversations about what it means for the Commonwealth to own the copyright of our flag and if any other models of community ownership were seriously considered. For the moment, this is a win.”

Labor Party Senator Malarndirri McCarthy said she would be scrutinising the deal during the Senate’s forthcoming budget estimates: “I look forward to scrutinising this deal and examining the details through Senate Estimates next month, in particular the copyright and custodianship of the flag”. McCarthy went on to state, “Scott Morrison and the Indigenous Affairs Minister need to also clarify where the money for this deal is coming from.”

Thursday, July 30, 2009

Eleven of the 25 workers at the Vestas factory in Newport, Isle of Wight, England who have been carrying out a sit-in since Monday July 20 have been sacked with immediate effect.

According to one of the protesters known as “Mike”, the occupiers were given their dismissal notices concealed under slices of their evening meal of pizza. The company said that the protesters have had ample opportunity to air their point of view, and had no choice but to sack eleven of the twenty five workers that they had positively identified; and that given that the fact that the action constituted a “fundamental breach” of trust, that the eleven would not be entitled to redundancy packages. A press release from the company said that Vestas “saw no other choice than to dismiss the 11 employees, who the company has positively identified as the employees currently participating in the occupation of the factory.”

The protesters remained upbeat, vowing to continue their occupation and have called upon the UK government to save the 625 jobs and to nationalise the Danish owned factory. Occupier Ian Terry told the BBC that if the occupiers are forced out, they plan to leave the building “peacefully”.

Vestas management were dealt a setback today in ending the occupation as Newport County Court ruled that the papers accusing the occupiers of aggravate trespass and requiring they surrender the office they occupy by July 29 were improperly served. The case has been adjourned until Tuesday August 4. In court, Judge Graham White said he was “distinctly uncomfortable” with what he perceived as Vestas’ effort to “get around the rules” in retaking the factory from the occupiers.

Legal representation for the Vestas workers had been offered by Bob Crow, secretary of the RMT trade union. Crow has pledged the “full solidarity” of the RMT and seven other unions with the workers occupying the plant.

Vestas management has also been providing the occupiers with hot meals in an apparent response to Crow’s announcement, made on July 24, that the RMT was planning on airlifting food into the factory by helicopter. Crow is meeting today with Ed Miliband, the Environment Minister.

Earlier in the week, Miliband pledged £6 million in funding to an expansion of Vestas’ Isle of Wight research and development centre, which currently employs 110 workers and could, said the Minister, be expanded to employ 40 more.

Rallies continued throughout the week in support of the Vestas occupiers. Since the occupation began, the Vestas workers have received declarations of support and solidarity from a wide swathe of the British left, including but not limited to: political parties Green Party, Respect, the Socialist Party, the Socialist Workers Party, the Alliance for Workers Liberty, and the Communist Party of Britain; the TUCG group, which brings together the BFAWU, FBU, NAPO, NUJ, PCS, POA, RMT, and URTU; and environmental groups Greenpeace, the Campaign against Climate Change, Climate Camp, and Workers’ Climate Action, who claims credit for initiating the campaign to occupy the factory. Attendees of the Big Green Gathering, a large annual environmentalist rally which was due to take place starting today but was suddenly canceled on Sunday, are being encouraged to go to the Isle of Wight and take part in support rallies for Vestas instead.

Speaking to Wikinews about the “red–green” coalition supporting the occupation, a spokesman for the Alliance for Workers’ Liberty said: “We think this struggle is important on at least three grounds — it is central to the struggle for jobs, it is central to the struggle for the environment, and it is central to the struggle for rebuilding the labour movement.”

Photographs shared with Wikinews by the occupiers show the occupiers, mostly young men, talking, carrying out everyday tasks, and keeping in touch with the outside world via mobile phones. The use of mobile telephones in the Vestas occupation has given the press remarkable access to the occupiers and provided an effective platform for relaying their demands and feelings to the media. In contrast, Vestas’s designated media contact for the United Kingdom is on vacation. Attempts to reach Vestas Newport factory manager Patrick Weir, whom a Vestas representative at the company’s Danish headquarters stated was handling press inquiries regarding the occupation, received no reply.

Vestas plans to close the factory on July 31, citing the difficulties of obtaining planning permission for wind farms in the United Kingdom. All blades manufactured at Vestas’ Newport plant are sent to the United States. 1900 employees of the company in Northern Europe face job losses, 625 of them in Vestas’s plants in the south of England.

Friday, November 9, 2007

Damir Voschion, 46, has reportedly killed five members of his family in Pula, Croatia on Thursday night around 7:00 p.m. CET (UTC+1). They were all killed by gunshots to the head. The victims include Damir’s two-month-old nephew, his seven-year-old niece, his brother, sister-in-law and then his father. The massacre took place in the family’s home.

Damir turned himself in to police after about an hour and confessed to them “I killed them all”. The bodies of the family have been transported to the morgue at the Pula General Hospital.

The motive for the massacre is not yet known, but there are theories that it might involve a property dispute between Damir and his brother. Neighbors say that Damir was a violent man and that at one time killed his brother’s dog with his bare hands.

Wednesday, September 23, 2009

Michael Jackson’s This Is It, a documentary film based on world-famous singer Michael Jackson rehearsing for his last tour before his untimely death, will be premiered in at least 15 cinemas in cities all over the world simultaneously.

The film is due to premiere on October 27 and October 28. The world cities may be in different time zones with different dates but they will all be premiering the film at exactly the same time. One such premiere location is Los Angeles, in the US state of California, which will have the film starting at 1800 PT. Another simultaneity is the Odeon Leicester Square cinema in London, England, which will start at 0100 GMT on October 27.

Other locations holding concurrent premieres are the South African city of Johannesburg, New York City in New York, German capital Berlin, Russian capital city Moscow, Japanese capital Tokyo, Australian city Sydney, French capital Paris, South Korean city Seoul, and Rio de Janeiro, a large city in Brazil.

Michael Jackson died on June 25, 2009 aged 50, after suffering from a cardiac arrest. The movie will feature some of the rehearsal footage made in the weeks before his death. In total, there will be at least 25 cinemas premiering the film, but not all of them will be released simultaneously. Sony Pictures, the film production company, have yet to announce the other cities involved. Tickets for the film will be available to purchase from Sunday, September 27. The film is directed by Kenny Ortega, who previously directed all the High School Musical films. He also directed some significant Michael Jackson events, such as his This Is It concert and Jackson’s memorial service.

Jeff Blake, chairman of worldwide marketing and distribution for Sony Pictures, said: “Michael Jackson has an army of fans everywhere around the world… we are giving the audiences an incredible opportunity to join together in celebration of Michael Jackson’s incredible career.”

[edit]